Plasma Membrane Ca ATPase 4 Is Required for Sperm Motility and Male Fertility*
نویسندگان
چکیده
From the ‡Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Josef-Schneider-Strasse 2, D-97080 Wuerzburg, Germany, the Biochemical Research and Study Center, University of Latvia, Ratsupites iela 1, Riga, LV-1067, Latvia, the **Department of Obstetrics and Gynecology, University of Wuerzburg, Josef-Schneider-Str. 2, D-97080 Wuerzburg, Germany, the ‡‡FMP, Krahmerstrasse 6, D-12207 Berlin, Germany, and the ¶Division of Cardiology, Room 1.302 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
منابع مشابه
Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Calcium and Ca(2+)-dependent signals play a crucial role in sperm motility and mammalian fertilization, but the molecules and mechanisms underlying these Ca(2+)-dependent pathways are incompletely understood. Here we show that homozygous male mice with a targeted gene deletion of isoform 4 of the plasma membrane calcium/calmodulin-dependent calcium ATPase (PMCA), which is highly enriched in the...
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Calcium (Ca) is a significant element that acts as an intracellular second messenger. It is necessary for many physiological processes in spermatozoa including spermatogenesis, sperm motility, capacitation, acrosome reaction and fertilization. Although influences of Calcium deficiency on sperm function and male infertility have been widely studied, mechanisms for these abnormalities are not wel...
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The relative importance of plasma membrane Ca2+-ATPase (PMCA) 1 and PMCA4 was assessed in mice carrying null mutations in their genes (Atp2b1 and Atp2b4). Loss of both copies of the gene encoding PMCA1 caused embryolethality, whereas heterozygous mutants had no overt disease phenotype. Despite widespread and abundant expression of PMCA4, PMCA4 null (Pmca4-/-) mutants exhibited no embryolethalit...
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Deletion of the gene encoding the widely conserved plasma membrane calcium ATPase 4 (PMCA4), a major Ca(2+) efflux pump, leads to loss of sperm motility and male infertility in mice. PMCA4's partners in sperm and how its absence exerts its effect on fertility are unknown. We hypothesize that in sperm PMCA4 interacts with endothelial nitric oxide synthase (eNOS) and neuronal nitric oxide synthas...
متن کاملActivity of the Na,K-ATPase alpha4 isoform is important for membrane potential, intracellular Ca2+, and pH to maintain motility in rat spermatozoa.
While the function of the ubiquitous Na,K-ATPase alpha1 subunit has been well documented, the role of the sperm-specific alpha4 isoform of this ion transporter is less known. We have explored the importance of alpha4 in rat sperm physiology by taking advantage of the high sensitivity of this isoform for the inhibitor ouabain. Using concentrations that selectively block alpha4 activity, we found...
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